The broad scientific question that REGENERATE-IT focuses on is why some animals regenerate while others do not, with the outlook of devising regenerative therapies in humans based on this knowledge.
The research projects envisioned within REGENERATE-IT aim to fill the clear gap in knowledge that exists at the fundamental and applied levels of regenerative biology: namely the missing link between regulatory mechanisms in stem cells and the morphogenic events in cells and tissues that define successful regenerative outcomes.
To approach this complex problem in a structured way, we have formulated three scientific questions, addressing them in three research themes, also called as work packages (WPs).
- WP1. How cell types are formed
- WP2. How tissues are formed
- WP3. How to control and manipulate regeneration