Karolinska Institutet (KI)
Limb regeneration in newts represents a unique example for how a complex body part can be rebuilt in vertebrates. Regeneration starts by rapid wound healing, followed by formation of a mesenchymal growth zone, called the blastema from which the new appendage originates. Blastema cells are generated from local stump tissues during which process several cell types undergo reprogramming. The focus of the project is to understand the molecular underpinnings of such reprogramming events with particular focus on the role of a group of miRNAs that bear the characteristic embryonic stem cell-specific cell cycle regulating seed and are regulated during limb regeneration. Of particular interest is whether and how these miRNAs regulate the dedifferentiation of terminally differentiated cells, which is a distinctive feature of newt limb regeneration.
András Simon, Ph.D.
Tel: +46-(0)8-524 870 20
Research in Simon’s group:
We try to understand regeneration mechanisms in newts, which are semiaquatic salamanders, and have the widest repertoire of regenerative abilities among vertebrates. We use several experimental paradigms divided into two main themes: Central nervous system and limb regeneration.
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Karolinska Institutet (KI) is one of the world’s foremost medical universities. Karolinska Institutet is Sweden’s single largest centre of medical academic research and offers the country’s widest range of medical courses and programmes. The research group is at the Department of Cell and Molecular Biology (CMB), comprising 30 independent research groups organized in three themes: Cell Biology, Developmental and Stem Cell Biology and Infection and Cancer. The research group is located in Biomedicum which harbors 5 preclinical departments with state of the art core facilities.